Uremia is a result of acute or chronic kidney failure. The kidneys fail to function properly leading to accumulation of toxic wastes circulating in the blood stream. These substances can cause considerable damage to other vital organs. Mental instability coupled with physical inefficiency is common in patients suffering from uremia.

Kidney failure is one of the primary reasons for this disease. Other reasons include surgery, trauma, electrolyte imbalance, water accumulation and urinary tract infections. Edema (accumulation of fluids) in facial and lower extremities, loss of appetite, apathy, delirium, anemia, epilepsy, muscle cramps, and skin ulcers are common symptoms of uremia. Low urine output is another characteristic feature. Insensitive to the surroundings, mental apathy and epilepsy can also occur in extreme conditions.

The total urine output in uremic patients can be as less as 400 ml in a 24-hour period. The osmolality concentration molar weight of urine is around 280 to 300 mm per kg. Urinary sodium concentrations are higher than normal. In acute kidney failure, the urine output drops to 35 ml per day. In final stages of kidney diseases, there could be minimum or no urine output at all.

The causes for uremia are varied. Kidneys are one of the vital organs in the body. Any damage to these organs can turn out to be fatal. Diagnosing the condition and taking timely treatment will go a long way in decreasing the severity of the disease. Following an appropriate diet plan and taking the prescribed medicines can significantly reduce the kidneys’ workload. This in turn will preserve the well-being of the body.

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